![]() Nestlé Health Science is a leader in the science of nutrition and a globally managed business unit of Nestlé. Nature’s Bounty is a Nestlé Health Science brand. Echinacea has been traditionally used for a variety of reasons, including for immune health, which dates back to the American Eclectics in the early part of the twentieth century. †Traditional use claims are based on historical or traditional practices. ^Compared to Nature's Bounty(R) Optimal Solutions(R) Hair, Skin & Nails gummies ◊ Source: Circana –Total US – Multi Outlet: Latest 52 weeks ending 11/26/23 Δ Get More With Nature’s Bounty® Than Ever Before. Please consult the label on the product that you purchased for the most accurate product information. Nature’s Bounty may make changes to products from time to time. These products are not intended to diagnose, treat, cure, or prevent any disease. Melatonin prevents sleep deprivation-associated anxiety-like behavior in rats: Role of oxidative stress and balance between GABAergic and glutamatergic transmission.*These statements have not been evaluated by the Food and Drug Administration. Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: A qualitative systematic review of randomized trials. The effect of melatonin on depressive symptoms, anxiety, circadian and sleep disturbances in patients after acute coronary syndrome (MEDACIS): Study protocol for a randomized controlled trial. A comparison of the effect of two doses of oral melatonin with oral midazolam and placebo on pre-operative anxiety, cognition and psychomotor function in children: A randomised double-blind study. Comparison of the effects of oral melatonin with oral alprazolam used as a premedicant in adult patients undergoing various surgical procedures under general anesthesia: A prospective randomized placebo-controlled study. ![]() Melatonin for pre- and postoperative anxiety in adults. Comparison of the effects of melatonin and oxazepam on anxiety levels and sleep quality in patients with ST-segment elevation myocardial infarction following primary percutaneous coronary intervention: A randomized clinical trial. Effect of melatonin administration on sleep, behavioral disorders and hypnotic drug discontinuation in the elderly: A randomized, double-blind, placebo-controlled study. Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Research shows that melatonin can be effective at reducing anxiety before surgical or medical procedures.īut it isn’t clear if it can help with other forms of anxiety, such as generalized anxiety disorder, social anxiety, and panic attacks. In this study, melatonin worked better than a placebo sugar pill to improve sleep and decrease symptoms of depression and anxiety. One older study also evaluated the effects of melatonin in older adults with sleep and mood disorders. ![]() In this study, melatonin worked better than oxazepam for improving sleep and reducing symptoms of anxiety. ![]() In another 2018 study, melatonin was evaluated in people who had just undergone a medical procedure to open up blood vessels in the heart. One 2018 study found that melatonin worked about as well as alprazolam for reducing anxiety before surgery. Some studies also found that melatonin reduced symptoms of anxiety after surgery, but other studies found no benefit. Most of the studies analyzed found that taking melatonin worked better than a placebo pill and about as well as midazolam for reducing anxiety before the procedure. In a 2015 analysis of clinical studies, melatonin was compared to either midazolam or a placebo sugar pill when given before surgery. It’s common for people to feel anxious before surgery and medications such as benzodiazepines are typically used to reduce these symptoms. Most of the human research on melatonin has been done in people who are undergoing a surgical procedure. Other medications commonly used for anxiety, such as benzodiazepines, also increase GABA levels. Higher GABA levels can have a calming effect and reduce symptoms of anxiety. In one 2017 animal study, melatonin increased levels of gamma-aminobutyric acid (GABA) in certain parts of the brain. In addition to improving sleep, melatonin has other effects that might improve symptoms of anxiety.
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